Dr. Richard Lewontin, the Alexander Agassiz Professor of Zoology at Harvard University, put it like this: "It is not that the methods and institutions of science somehow compel us to accept a material explanation of the phenomenal world, but, on the contrary, that we are forced by our a priori adherence to material causes to create an apparatus of investigation and a set of concepts that produce material explanations, no matter how counterintuitive, no matter how mystifying to the uninitiated. Moreover, that materialism is absolute, for we cannot allow a Divine Foot in the door" (bold text theirs)
If, on the other hand, I were neutral, and didn't already have an "a priori adherence" to a particular worldview (be it naturalistic or otherwise), the question "does God really exist?" wouldn't be pointless at all. Rather, it would be the first step in an objective and meaningful search for ultimate truth. Our willingness to ask the question with an open mind is fundamental to our ability to discover the truth behind the answer. So first of all, before you even ask the question, decide whether or not you're really willing to accept the answer.